Publication of a Research Article on the DEEPCT
Basgenbio Monthly NEWSLETTER
January 2024
Newly Published Original Research Article on the Drug Efficacy Simulation Solution
📌 Basgenbio is proud to announce the recent publication of an Original Research Article using the Drug Efficacy Simulation Solution, DEEPCT (DEEP learning-based Clinical Trials), in the latest issue of the leading SCI journal, Scientific Reports.

📌 In this study, the effects of 'Xanthine Oxidase Inhibitors (XOIs)' on cardiovascular diseases were evaluated. XOIs, including allopurinol and febuxostat, have been used primarily for treating gout, as their antioxidative properties help reduce the production of reactive oxygen species. These antioxidative activities are expected to positively impact cardiovascular disease; however, the exact nature of this causality remains unknown.

📌 Our results indicate that urate reducers not only lower the risk of stroke but also hold potential in treating acute myocardial infarction, particularly in individuals with high serum triglyceride levels.


*Title : Effects of uric acid on ischemic disease, stratified by cholesterol levels: a drug-target, nonlinear Mendelian randomization study

📌 Eight out of 10 drug candidates identified using the 'DEEPCT' platform through drug repurposing analysis demonstrated an increase in the proliferation of human hair follicle dermal papilla cells (HFDPCs) in cases of male pattern hair loss. Furthermore, three of these candidates exhibited proliferation increases that were both time- and dose-dependent, indicating a relationship with dosage strength and duration.

*Using 'DEEPCT', it took only 3 months to progress from candidate discovery to the completion of the cell experiment.

📌 Global IR @ JPM 2024

 - During the IR Pitching Event for Biotech Startups at Nasdaq Entrepreneurial Center, Basgenbio showcased the innovative Drug Efficacy Simulation Solution 'DEEPCT', along with significant research outcomes.

 - Basgenbio's 'DEEPCT' solution optimises the drug development process for pharmaceutical companies based on high level of scientific evidence.

📌 Selected in the 2023 'LG SUPERSTART Incubator' program.

 - Basgenbio is selected in the LG SUPERSTART Incubator program within the pharmaceutical and biotechnology sector. (1:84 chance)

 - Basgenbio is expected to revolutionize its pipelines through collaboration with LG subsidiaries.

📌 KSB Tugen and Basgenbio have successfully completed the efficacy validation of a drug candidate for aging muscle atrophy, 'KSB-10301', using 'DEEPCT'.

 - 'KSB-10301' demonstrated significant efficacy compared to drug candidates that have failed in the process of global clinical trial, as well as local competitors currently under development.

 - A global joint technology transfer agreement has been concluded, involving the analysis results from 'DEEPCT,' to augment the asset value.

📌 Signed partnership agreement for AI-based bio big data commercialization with Hancom Carelink & 3BIGS

 - The collaboration involves three parties in the field of bio big data, aiming to integrate data handling capabilities and analytical expertise.

 - Our aim is to create an ultimate large-scale multi-omics cohort for research and to discover novel biomarkers.

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